Enzymind Labs

This ScienceDaily item touches on the relationship between mood/affect and creativity: 

Video Games Can Make Us Creative If Spark Is Right

Video games that energize players and induce a positive mood could also enhance creativity, according to media researchers. However, the study also finds that players who were not highly energized and had a negative mood, registered the highest creativity.

"You need defocused attention for being creative," said S. Shyam Sundar, professor of film, video and media studies at Penn State. "When you have low arousal and are negative, you tend to focus on detail and become more analytical."

Sundar and Elizabeth Hutton, a Penn State graduate student, are trying to understand the value of video games as a vehicle for sparking positive social traits, such as creativity. Fun and games aside, video games are viewed as a serious communication technology. Schools, corporations and even the government are increasingly employing it as a tool in enhancing learning and decision-making.

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My creative pursuits are generally detail and analytically oriented -- poking pixels and debugging code. I've wondered if negative mood contributes to this process. I've found that when I'm not feeling well, with migraine illness that supresses motivation and clarity of thought, is also the time when I slowly dink at very focused and circumscribed tasks. It seems that it is when I'm zoning on one of these problems that new ideas often crop up.